Books : Enhancement of spatial navigation ability in older rats following chronic administration of the alpha2 noradrenergic antagonist piperoxane.: An article from: The Psychological Record
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Type of bind: Digital
Format: HTML
Label: Psychological Record
Manufacturer: Psychological Record
Page Count: 16
Printing Date: March 22, 1997
Publishing house: Psychological Record
Release Date: July 28, 2005
Studio: Psychological Record
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This digital document is an article from The Psychological Record, published by Psychological Record on March 22, 1997. The length of the article is 4614 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: The noradrenergic system of the locus coeruleus has been implicated in a variety of processes including reinforcement, attention, and acquisition and retention of learned behaviors. Its dense projections, some of which are shared by the cholinergic system, provide an ideal network within which to study the cognitive impairments related to aging. The current investigation explored the effects of piperoxane, an [[Alpha].sub.2] noradrenergic receptor antagonist, on the performance of 18- and 24-month-old rats in the Morris water maze and a step-down passive avoidance task. Piperoxane injections (3 mg/kg, IP) facilitated the performance of the 18-month-old animals to levels comparable to those of the 8-month-old saline controls in constant-start, novel-start, and goal rotation testing variations of the Morris water maze. With the exception of the 24-month-old saline control group, all rats displayed retention on the step-down passive-avoidance task when tested 24 hours after training.
Citation Details
Title: Enhancement of spatial navigation ability in older rats following chronic administration of the alpha2 noradrenergic antagonist piperoxane.
Author: David M. Compton
Publication: The Psychological Record (Refereed)
Date: March 22, 1997
Publishing house: Psychological Record
Volume: v47 Issue: n2 Page: p321(14)
Distributed by Thomson Gale
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